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Betamethasone 500 mcg tablets and 2.0 mg/kg phentolamine/day. The dose was reduced to 1.0 mg/kg phentolamine after 1 week. Toxicity The of difenfy in BALB/c mice were similar, i.e. it caused a decrease in body organ weights and no other serious toxic effects. Postmarketing Reports of Toxic Reaction Fatalities In Canada November 2004, a patient receiving the difenfy tablet was admitted to hospital with severe respiratory depression, hyperthermia, and convulsions. Blood organ toxicology tests proved negative. In the USA February 2000 and 1997 respectively, the patient with pulmonary involvement died after receiving the drug, and liver kidney toxicology tests were negative. In 1999, the US Food and Drug Administration (FDA) approved difenfy for use as precautions and emergency treatment (see section 4.5 Precautions in the CONTRAINDICATIONS and WARNINGS section). In Europe and Japan, there have not been any reported deaths due to tetracycline sulfonamide (Difenfy). In Japan, it is believed that the tetracycline sulfonamide (Difenfy-1) may be associated with severe renal failure in individuals taking difenfy at doses similar to those used in USA.[3] There have been three deaths which reported to the Japanese government. clinical signs and symptoms |